Last update
3/17/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.8
Supplement Facts
Serving Size: 2 Vegetarian Capsules
Amount Per Serving
%DV
Thiamine (vitamin B1) (as thiamine HCl)
100 mg
8333%
Riboflavin (vitamin B2) (as riboflavin and riboflavin 5'-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
100 mg•
625%
Vitamin B6 (as pyridoxine HCl and pyridoxal 5' phosphate)
100 mg
5882%
Folate (as L-5-methyltetrahydrofolate calcium salt)
680 mcg○
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12500%
Biotin
1000 mcg
3333%
Pantothenic acid (as D-calcium pantothenate)
500 mg
10000%
Calcium (as D-calcium pantothenate, dicalcium phosphate)
50 mg
4%
Inositol
100 mg
**
PABA (para-aminobenzoic acid)
50 mg
**
Top Medical Research Studies
8
We examined the effects of folic acid supplementation on blood clot events in patients with end-stage kidney disease (ESKD). Analyzing data from over 2,000 patients, we divided them into daily and weekly supplementation groups for a mean follow-up of 5.8 years.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
Read More
8
We investigated how folic acid (FA) affects blood clotting in response to carbon black exposure. Adult mice were exposed to filtered air or carbon black for 28 days. We found that carbon black increased blood clotting and spurred the development of a certain type of blood cells in the spleen. Interestingly, while carbon black lowered folic acid levels, administering FA helped restore normal coagulation by inhibiting certain enzymes in spleen macrophages. This suggests that folic acid could be beneficial in protecting against increased clotting risks related to carbon black exposure.
Read More
8
In this case, we observed a 19-year-old man who developed severe peripheral neuropathy and central pulmonary embolism after using nitrous oxide recreationally. Elevated levels of homocysteine and methylmalonic acid indicated vitamin B₁₂ inactivation due to the substance. After discontinuing nitrous oxide and undergoing treatment with B vitamins for six months, the patient showed remarkable recovery, with symptoms significantly reduced. This highlights that even low levels of nitrous oxide use can lead to serious health issues, including increased blood clot risks. Awareness is crucial for young individuals who may use this substance.
Read More
Most Useful Reviews
7.5
Improved mood
4 people found this helpful
This dietary supplement improved my psychological state and mood. Monitoring homocysteine levels was excellent while taking it, and I found the vitamins vital for development during pregnancy, despite the colour change in urine.
Read More
9
Life-changing supplement
2 people found this helpful
This supplement has been truly life-changing for me! Having the MTHFR gene mutation, which affects about 30% of the population, this B Complex has transformed my life due to its activated forms of B9 and B12. My blood tests support this improvement. I now feel full of energy and zest for life.
Read More
7.5
Essential for mutations
95 people found this helpful
I call fellow users "mutants" for their folate cycle mutations. This vitamin is vital for those like me with specific gene mutations affecting B9 and B12 absorption. I now monitor my homocysteine and control blood clotting better since I began this regimen.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
- All Researches
8
We examined the impact of vitamin B12 deficiency on cerebral venous sinus thrombosis (CVST) through a case series involving three patients. Each case presented symptoms like headaches and, in some instances, visual disturbances. All patients showed elevated homocysteine levels and had low vitamin B12. Treatment included anticoagulation therapy and vitamin supplementation, leading to positive responses and, in two cases, resolution of thrombosis. This suggests that monitoring vitamin B12 levels, particularly in vegetarian diets, is crucial and could help prevent CVST.
Read More
8
Vitamin B12 aids in thromboembolism recovery
We observed a rare case of cerebral venous thrombosis (CVT) associated with hyperhomocysteinemia and iron-deficiency anemia due to autoimmune gastritis.
The patient, a 47-year-old woman, experienced serious symptoms like impaired consciousness and motor difficulties. After thorough examinations like CT and MRI, she was treated with anticoagulants and given iron and vitamin B12 supplements.
Remarkably, the patient showed significant improvement and was discharged without neurological deficits, highlighting the potential role of vitamin B12 and iron in managing conditions linked to blood clots.
The patient, a 47-year-old woman, experienced serious symptoms like impaired consciousness and motor difficulties. After thorough examinations like CT and MRI, she was treated with anticoagulants and given iron and vitamin B12 supplements.
Remarkably, the patient showed significant improvement and was discharged without neurological deficits, highlighting the potential role of vitamin B12 and iron in managing conditions linked to blood clots.
Read More
8
We examined the effects of folic acid supplementation on blood clot events in patients with end-stage kidney disease (ESKD). Analyzing data from over 2,000 patients, we divided them into daily and weekly supplementation groups for a mean follow-up of 5.8 years.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
Read More
8
We investigated how folic acid (FA) affects blood clotting in response to carbon black exposure. Adult mice were exposed to filtered air or carbon black for 28 days. We found that carbon black increased blood clotting and spurred the development of a certain type of blood cells in the spleen. Interestingly, while carbon black lowered folic acid levels, administering FA helped restore normal coagulation by inhibiting certain enzymes in spleen macrophages. This suggests that folic acid could be beneficial in protecting against increased clotting risks related to carbon black exposure.
Read More
8
In this case, we observed a 19-year-old man who developed severe peripheral neuropathy and central pulmonary embolism after using nitrous oxide recreationally. Elevated levels of homocysteine and methylmalonic acid indicated vitamin B₁₂ inactivation due to the substance. After discontinuing nitrous oxide and undergoing treatment with B vitamins for six months, the patient showed remarkable recovery, with symptoms significantly reduced. This highlights that even low levels of nitrous oxide use can lead to serious health issues, including increased blood clot risks. Awareness is crucial for young individuals who may use this substance.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved mood
4 people found this helpful
This dietary supplement improved my psychological state and mood. Monitoring homocysteine levels was excellent while taking it, and I found the vitamins vital for development during pregnancy, despite the colour change in urine.
Read More
9
Life-changing supplement
2 people found this helpful
This supplement has been truly life-changing for me! Having the MTHFR gene mutation, which affects about 30% of the population, this B Complex has transformed my life due to its activated forms of B9 and B12. My blood tests support this improvement. I now feel full of energy and zest for life.
Read More
7.5
Essential for mutations
95 people found this helpful
I call fellow users "mutants" for their folate cycle mutations. This vitamin is vital for those like me with specific gene mutations affecting B9 and B12 absorption. I now monitor my homocysteine and control blood clotting better since I began this regimen.
Read More
6
Improved circulation observed
9 people found this helpful
This product is incredibly effective. After taking it, I developed a red rash that resembled hives, but it faded in about half an hour. I suspected it was a niacin flush, yet I believe it's a symptom of enhanced blood circulation, which has been poor for me historically. The product's quality seems excellent, so I will keep using it.
Read More
7.5
Improved homocysteine levels
7 people found this helpful
I appreciated the effect on my psychological state and blood counts during pregnancy. The vitamin improved homocysteine levels, vital for development. The bright yellow urine is a normal side effect.
Read More
Frequently Asked Questions
2
Increased blood pressure
2 people found this helpful
It didn’t suit me, apparently due to the niacin (B3), which dilates blood vessels. Initially, it was fine, but the following day my blood pressure surged. As someone with hypertension, I found that after taking this vitamin complex, my blood pressure increased sharply. The subsequent doses did not provide the same beneficial effect as the first intake.
7.5
Essential for mutations
95 people found this helpful
I call fellow users "mutants" for their folate cycle mutations. This vitamin is vital for those like me with specific gene mutations affecting B9 and B12 absorption. I now monitor my homocysteine and control blood clotting better since I began this regimen.
6
Blood circulation boost
1 people found this helpful
Initially, when I took two capsules on an empty stomach, I experienced a niacin flush with spots on my arm, but this resolved within 30 minutes. I switched to one capsule and monitored the situation, noting an improvement in my blood circulation. I intend to continue this regime, as I feel physically well.
8
We examined the impact of vitamin B12 deficiency on cerebral venous sinus thrombosis (CVST) through a case series involving three patients. Each case presented symptoms like headaches and, in some instances, visual disturbances. All patients showed elevated homocysteine levels and had low vitamin B12. Treatment included anticoagulation therapy and vitamin supplementation, leading to positive responses and, in two cases, resolution of thrombosis. This suggests that monitoring vitamin B12 levels, particularly in vegetarian diets, is crucial and could help prevent CVST.
8
Vitamin B12 aids in thromboembolism recovery
We observed a rare case of cerebral venous thrombosis (CVT) associated with hyperhomocysteinemia and iron-deficiency anemia due to autoimmune gastritis.
The patient, a 47-year-old woman, experienced serious symptoms like impaired consciousness and motor difficulties. After thorough examinations like CT and MRI, she was treated with anticoagulants and given iron and vitamin B12 supplements.
Remarkably, the patient showed significant improvement and was discharged without neurological deficits, highlighting the potential role of vitamin B12 and iron in managing conditions linked to blood clots.
The patient, a 47-year-old woman, experienced serious symptoms like impaired consciousness and motor difficulties. After thorough examinations like CT and MRI, she was treated with anticoagulants and given iron and vitamin B12 supplements.
Remarkably, the patient showed significant improvement and was discharged without neurological deficits, highlighting the potential role of vitamin B12 and iron in managing conditions linked to blood clots.
8
We examined the effects of folic acid supplementation on blood clot events in patients with end-stage kidney disease (ESKD). Analyzing data from over 2,000 patients, we divided them into daily and weekly supplementation groups for a mean follow-up of 5.8 years.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
8
We investigated how folic acid (FA) affects blood clotting in response to carbon black exposure. Adult mice were exposed to filtered air or carbon black for 28 days. We found that carbon black increased blood clotting and spurred the development of a certain type of blood cells in the spleen. Interestingly, while carbon black lowered folic acid levels, administering FA helped restore normal coagulation by inhibiting certain enzymes in spleen macrophages. This suggests that folic acid could be beneficial in protecting against increased clotting risks related to carbon black exposure.
References
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. 10.4103/aam.aam_138_23
- Mochizuki T, Ryu B, Kushi K, Shima S, Sato S, et al. Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review. Neuroradiol J. 2023;36:491. 10.1177/19714009221147224
- Tu YR, Tu KH, Lee CC, Fan PC, Yen CL, et al. Supplementation with Folic Acid and Cardiovascular Outcomes in End-Stage Kidney Disease: A Multi-Institution Cohort Study. Nutrients. 2022;14. 10.3390/nu14194162
- Meng Q, Li B, Huang N, Wei S, Ren Q, et al. Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential. J Hazard Mater. 2022;424:127354. 10.1016/j.jhazmat.2021.127354
- Pedersen OB, Hvas AM, Grove EL. A 19-Year-Old Man with a History of Recreational Inhalation of Nitrous Oxide with Severe Peripheral Neuropathy and Central Pulmonary Embolism. Am J Case Rep. 2021;22:e931936. 10.12659/AJCR.931936
- Al Sulaiman K, Aljuhani O, Al Dossari M, Alshahrani A, Alharbi A, et al. Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study. Crit Care. 2021;25:223. 10.1186/s13054-021-03648-9
Data last updated:
